Brink Therapeutics is a venture-backed biotech company specializing in the development of cutting-edge gene therapy tools. We focus on site-specific recombinases, highly efficient enzymes that enable precise DNA modifications—such as inserting, removing, or inverting DNA sequences—without causing double-strand breaks. These recombinases offer a safer, more precise alternative to existing technologies like CRISPR-Cas9, giving them the potential to revolutionize Cell and Gene Therapies and finally push them over the brink of mass accessibility.

Values

By joining Brink Therapeutics, you will become one of our first team members, and experience the thrill of helping to build an ambitious new company harnessing advanced Directed Evolution, deep gene-mining techniques and AI to unlock new possibilities for treating & curing cancers, autoimmune diseases, genetic disorders and beyond.

If you are an innovative scientist or engineer excited about working together to solve hard, longstanding problems to improve patients’ lives around the world, we are looking for passionate individuals to join our team and help shape the future of medicine!
 

Mission Highlights
As a Senior Scientist in Molecular Biology, you will be responsible for innovating, optimizing and overseeing the execution of our advanced in vitro droplet-based recombinase Directed Evolution platform, with the ultimate goals of generating and characterizing in vitro lead recombinase enzyme candidates of high therapeutic utility and generating massive NGS datasets for computational colleagues to extract learnings from. 

Responsibilities

• Develop & execute processes for the design and generation of ultra-large, smart
  recombinase variant libraries (in collaboration with computational scientists)
• Develop & execute in vitro droplet-based recombinase Directed Evolution assays starting
  from our existing platform (microfluidics expertise not required
•  Develop & execute NGS-based processes for efficient readout of Directed Evolution assays
• Develop & execute in vitro assays for the rapid characterization of key recombinase
  functional and biochemical properties
• Communicate project status, requirements, risks and mitigation to stakeholders
• Perform critical data analysis (with computational scientist support as needed), maintain detailed electronic laboratory records, present results to stakeholders
• Disclose research innovations to internal stakeholders to secure IP protection
• Mentor & coach junior team members`

Competencies

You feel at home in the wet lab, designing experiments and generating & interpreting data. You enjoy communicating your findings in a clear and actionable manner, particularly to fellow scientists in both the wet and dry lab. You are conscious of maximizing the value of your research activities by employing good documentation practices. You are a sharp and collaborative trouble-shooter who doesn’t shy away from the hard problems.

Required:

• MSc with 5+ years of experience or PhD with 2+ years of experience in molecular biology, biochemistry or related fields, and eagerness to keep learning
• Proven record of innovative and independent problem-solving skills
  
• Demonstrated expertise in experimental design, assay development and data analysis
• Project management experience
• Excellent written and oral communication
• English - professional working proficiency
• Motivation to work in a flexible and fast-paced startup

The ideal candidate will also have some of the following:

• Experience working in startup environment
• Expertise in Directed Evolution, gene library synthesis, and NGS
  
• Expertise in recombinase enzymology

Recruitment Process

• We first check that your profile meets our requirements
• An introductory call with the CEO (and cofounder) Jonathan Naccache
• Technical interview with the CTO (and cofounder) Harry Kemble
• Value fit interviews with the rest of the team, on-site

Why joining us?

• Unique opportunity to be part of an early-stage biotech company, shaping the future of genome editing for Cell and Gene Therapy
• Competitive salary + benefits package
• Beautiful, well-equipped offices & labs in the heart of Paris, filled with great plants and great people.

If you're excited about helping revolutionize genome editing and opening up Cell & Gene Therapy to the millions who could benefit, apply now, and let's make the difference together!